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  • 홍승모 교수

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    소화기병리

    소속연구단

    관련/관심분야

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    주요논문

    1. Somatostatin receptor 2 (SSTR2) expression is associated with better clinical outcome and prognosis in rectal neuroendocrine tumors [ SCIENTIFIC REPORTS ] - 2024.02.19
    2. Gastric Neuroendocrine Tumors According to the 2019 World Health Organization Grading System: A Single-Center, Retrospective Study [ Gut and Liver ] - 2023.11.01
    3. Prognostic significance of extranodal extension of nodal metastasis in adenocarcinoma of the ampulla of Vater [ HUMAN PATHOLOGY ] - 2023.07.01
    4. Clinicopathologic Impact of Peptide Hormonal Expression in Rectal Neuroendocrine Tumors [ ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE ] - 2023.07.01
    5. Frequent Intraluminal Growth of Large Muscular Veins in Surgically Resected Colorectal Cancer Tissues: A 3-Dimensional Pathologic Reconstruction Study [ MODERN PATHOLOGY ] - 2023.03.01
    6. Combined Infiltrative Macroscopic Growth Pattern and Infiltrative Microscopic Tumor Border Status Is a Novel Surrogate Marker of Poor Prognosis in Patients With Pancreatic Neuroendocrine Tumor [ ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE ] - 2023.01.01
    7. Pancreatic ductal adenocarcinoma with a predominant large duct pattern has better recurrence-free survival than conventional pancreatic ductal adenocarcinoma: a comprehensive histopathological, immunohistochemical, and mutational study [ HUMAN PATHOLOGY ] - 2022.09.01
    8. The T Category of Distal Extrahepatic Bile Duct Carcinoma: A Comparative Analysis With Invasive Tumor Thickness [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2022.07.01
    9. The Prognostic Reliability of Lymphovascular Invasion for Patients with T3N0 Colorectal Cancer in Adjuvant Chemotherapy Decision Making [ Cancers ] - 2022.06.08
    10. Double Ki-67 and synaptophysin labeling in pancreatic neuroendocrine tumor biopsies [ PANCREATOLOGY ] - 2022.04.01
    11. Granulocytic epithelial lesion (GEL) in heterotopic pancreas [ PANCREATOLOGY ] - 2022.04.01
    12. High YAP and TEAD4 immunolabelings are associated with poor prognosis in patients with gallbladder cancer [ APMIS ] - 2021.12.01
    13. Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma [ LIVER INTERNATIONAL ] - 2021.10.01
    14. Expression of HER2 and Mismatch Repair Proteins in Surgically Resected Gallbladder Adenocarcinoma [ FRONTIERS IN ONCOLOGY ] - 2021.07.22
    15. Prognostic implication of SOX2 expression in small intestinal adenocarcinoma [ VIRCHOWS ARCHIV ] - 2021.06.01
    16. Large tumor size, lymphovascular invasion, and synchronous metastasis are associated with the recurrence of solid pseudopapillary neoplasms of the pancreas [ HPB ] - 2021.02.01
    17. Distribution pattern of tumor infiltrating lymphocytes and tumor microenvironment composition as prognostic indicators in anorectal malignant melanoma [ MODERN PATHOLOGY ] - 2021.01.01
    18. Desmin and CD31 immunolabeling for detecting venous invasion of the pancreatobiliary tract cancers [ PLoS One ] - 2020.11.30
    19. Chromogranin A Expression in Rectal Neuroendocrine Tumors Is Associated With More Aggressive Clinical Behavior and a Poorer Prognosis [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2020.11.01
    20. Comprehensive histological evaluation with clinical analysis of venous invasion in pancreatic ductal adenocarcinoma: From histology to clinical implications. [ PANCREATOLOGY ] - 2020.10.01
    21. Lymph node size and its association with nodal metastasis in ductal adenocarcinoma of the pancreas [ Journal of Pathology and Translational Medicine ] - 2020.09.01
    22. Tumor Budding and Poorly Differentiated Clusters in Small Intestinal Adenocarcinoma [ Cancers ] - 2020.08.06
    23. Clinicopathologic and Prognostic Significance of Gallbladder and Cystic Duct Invasion in Distal Bile Duct Carcinoma [ ARCHIVES OF PATHOLOGY LABORATORY MEDICINE ] - 2020.06.01
    24. Smooth Muscle Distribution Patterns of Choledochal Cysts and Their Implications for Pathogenesis and Postoperative Complications. [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2020.05.05
    25. Clinicopathological significance of olfactomedin-4 in extrahepatic bile duct carcinoma [ PATHOLOGY RESEARCH AND PRACTICE ] - 2020.05.01
    26. Pancreatic acinar cell carcinomas and mixed acinar-neuroendocrine carcinomas are more clinically aggressive than grade 1 pancreatic neuroendocrine tumours [ PATHOLOGY ] - 2020.04.01
    27. Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion [ MODERN PATHOLOGY ] - 2020.04.01
    28. Validation of the 8th Edition of the American Joint Committee on Cancer Staging System or Gallbladder Cancer and Implications for the Follow-up of Patients without Node Dissection [ CANCER RESEARCH AND TREATMENT ] - 2020.04.01
    29. Pancreatic High-Grade Neuroendocrine Neoplasms in the Korean Population: A Multicenter Study [ CANCER RESEARCH AND TREATMENT ] - 2020.01.02
    30. Prognostic Significance of Stromal and Intraepithelial Tumor-Infiltrating Lymphocytes in Small Intestinal Adenocarcinoma [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2020.01.01
    31. Multiple KRAS mutations in the non-mucinous epithelial lining in the majority of mucinous cystic neoplasms of the pancreas [ HISTOPATHOLOGY ] - 2019.10.01
    32. Prediction of Recurrence With KRAS Mutational Burden Using Ultrasensitive Digital Polymerase Chain Reaction of Radial Resection Margin of Resected Pancreatic Ductal Adenocarcinoma [ PANCREAS ] - 2019.03.01
    33. High-grade precursor lesions can be used as surrogate markers to identify the epicenter of periampullary carcinomas [ HUMAN PATHOLOGY ] - 2019.02.01
    34. A "Clearer" View of Pancreatic Pathology: A Review of Tissue Clearing and Advanced Microscopy Techniques. [ ADVANCES IN ANATOMIC PATHOLOGY ] - 2019.01.02
    35. Validation of the Eighth American Joint Committee on Cancer Staging System for Distal Bile Duct Carcinoma. [ CANCER RESEARCH AND TREATMENT ] - 2019.01.02
    36. FGFR1 expression defines clinically distinct subtypes in pancreatic cancer [ JOURNAL OF TRANSLATIONAL MEDICINE ] - 2018.12.28
    37. Grading by the Ki-67 Labeling Index of Endoscopic Ultrasound-Guided Fine Needle Aspiration Biopsy Specimens of Pancreatic Neuroendocrine Tumors Can Be Underestimated [ PANCREAS ] - 2018.11.01
    38. Prognosis of Pancreatic Cancer Patients with Synchronous or Metachronous Malignancies from Other Organs Is Better than Those with Pancreatic Cancer Only [ CANCER RESEARCH AND TREATMENT ] - 2018.10.01
    39. Significance of microcystic, elongated, and fragmented glandular-like features in intraductal papillary mucinous neoplasm of the pancreas [ HUMAN PATHOLOGY ] - 2018.08.01
    40. High-grade PanIN presenting with localised stricture of the main pancreatic duct: A clinicopathological and molecular study of 10 cases suggests a clue for the early detection of pancreatic cancer [ HISTOPATHOLOGY ] - 2018.08.01
    41. Carbonic anhydrase 9 expression in well-differentiated pancreatic neuroendocrine neoplasms might be associated with aggressive behavior and poor survival. [ VIRCHOWS ARCHIV ] - 2018.05.01
    42. Validation of the eighth edition of the American Joint Committee on Cancer staging system for ampulla of Vater cancer [ SURGERY ] - 2018.05.01
    43. Xanthogranulomatous cholecystitis shows overlapping histological features with IgG4-related cholecystitis [ HISTOPATHOLOGY ] - 2018.03.02
    44. Precursor Lesions of Pancreatic Cancer [ ONCOLOGY RESEARCH AND TREATMENT ] - 2018.01.01
    45. Incipient serous cystic neoplasia of the pancreas is a very rare phenomenon: a systematic prospective observation in pancreatectomy specimens?reply [ HUMAN PATHOLOGY ] - 2017.12.01
    46. Heterotopic Pancreas of the Gastrointestinal Tract and Associated Precursor and Cancerous Lesions: Systematic Pathologic Studies of 165 Cases [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2017.06.01
    47. Establishment and characterization of 6 novel patient-derived primary pancreatic ductal adenocarcinoma cell lines from Korean pancreatic cancer patients [ Cancer Cell International ] - 2017.04.20
    48. Lynch syndrome-related small intestinal adenocarcinomas. [ Oncotarget ] - 2017.03.28
    49. Alternative Lengthening of Telomeres in Primary Pancreatic Neuroendocrine Tumors Is Associated with Aggressive Clinical Behavior and Poor Survival [ CLINICAL CANCER RESEARCH ] - 2017.03.15
    50. CD133 expression in well-differentiated pancreatic neuroendocrine tumors: a potential predictor of progressive clinical courses [ HUMAN PATHOLOGY ] - 2017.03.01
    51. Pancreatic serous cystic neoplasms accompanying other pancreatic tumors [ HUMAN PATHOLOGY ] - 2017.02.01
    52. Recent Updates on Neuroendocrine Tumors From the Gastrointestinal and Pancreatobiliary Tracts. [ ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE ] - 2016.05.01
    53. Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinoma. [ MODERN PATHOLOGY ] - 2016.04.01
    54. Alpha-Synuclein in Gastric and Colonic Mucosa in Parkinson’s Disease : Limited role as a biomarker. [ MOVEMENT DISORDERS ] - 2016.02.01
    55. A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas. [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2015.12.01
    56. Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases. [ HUMAN PATHOLOGY ] - 2015.06.01
    57. Clinicopathologic and prognostic significance of multiple hormone expression in pancreatic neuroendocrine tumors [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2015.05.04
    58. Non-L-cell Immunophenotype and Large Tumor Size in Rectal Neuroendocrine Tumors Are Associated With Aggressive Clinical Behavior and Worse Prognosis. [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2015.05.04
    59. Survival effect of tumor size and extrapancreatic extension in surgically resected pancreatic cancer: proposal for improved T classification. [ HUMAN PATHOLOGY ] - 2014.11.01
    60. Prognostic significance of CDX2 and mucin expression in small intestinal adenocarcinoma. [ MODERN PATHOLOGY ] - 2014.10.01
    61. Primary mesenchymal tumors of the pancreas: single-center experience over 16 years. [ PANCREAS ] - 2014.08.01
    62. S100A4 expression is a prognostic indicator in small intestine adenocarcinoma. [ JOURNAL OF CLINICAL PATHOLOGY ] - 2014.03.09
    63. Increased number of metastatic lymph nodes in adenocarcinoma of the ampulla of Vater as a prognostic factor: A proposal of new nodal classification. [ SURGERY ] - 2014.01.02
    64. Pleomorphic solid pseudopapillary neoplasm of the pancreas: degenerative change rather than high-grade malignant potential [ HUMAN PATHOLOGY ] - 2014.01.01
    65. Combined Loss of E-cadherin and Aberrant β-Catenin Protein Expression Correlates With a Poor Prognosis for Small Intestinal Adenocarcinomas [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2013.02.01
    66. Loss of S100A14 Expression Is Associated with the Progression of Adenocarcinomas of the Small Intestine [ PATHOBIOLOGY ] - 2013.01.01
    67. HER3 overexpression is a prognostic indicator of extrahepatic cholangiocarcinoma [ VIRCHOWS ARCHIV ] - 2012.11.01
    68. Oncologic outcome after preoperative chemoradiotherapy in patients with pathologic T0 (ypT0) rectal cancer. [ DISEASES OF THE COLON & RECTUM ] - 2012.10.01
    69. Genome-wide somatic copy number alterations in low-grade panINs and IPMNs from individuals with a family history of pancreatic cancer [ CLINICAL CANCER RESEARCH ] - 2012.08.01
    70. Vascular Invasion in Infiltrating Ductal Adenocarcinoma of the Pancreas Can Mimic Pancreatic Intraepithelial Neoplasia: A Histopathologic Study of 209 Cases [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2012.02.01

    연구과제 수주실적

    1. 신속 고해상도 고대비도 광학 조직검사를 위한 경사라인스캔 다중 현미경 기술개발 - 2022.03.01 ~ 2022.12.31
    2. 췌장암의 혈관침범 바이오마커 개발과 기전 규명 - 2022.03.01 ~ 2023.02.28
    3. 병리진단을 위한 홀로그램 편광 토모그래피 기술개발 - 2022.01.01 ~ 2022.12.31
    4. 병리진단을 위한 홀로그램 편광 토모그래피 기술개발 - 2021.04.01 ~ 2021.12.31
    5. (2020, 기본) 췌장암의 혈관침범 바이오마커 개발과 기전 규명 - 2021.03.01 ~ 2022.02.28
    6. (세부, 2차, 산자부)신속 고해상도 고대비도 광학 조직검사를 위한 경사라인스캔 다중 현미경 기술개발 - 2021.03.01 ~ 2022.02.28
    7. 면역단백 프로파일(immunoprotein profile)을 이용한 항문직장 악성흑색종(anorectal malignant melanoma)환자의 예후 및 치료 반응성 예측 - 2021.01.01 ~ 2021.12.31
    8. (세부, 2차, 산자부)신속 고해상도 고대비도 광학 조직검사를 위한 경사라인스캔 다중 현미경 기술개발 - 2020.09.01 ~ 2021.02.28
    9. Promer 기술이 적용된 miRNA 분석기반 조기 암진단키트 및 암 스크리닝 서비스 - 2020.06.26 ~ 2021.06.25
    10. 췌장암의 혈관침범 바이오마커 개발과 기전 규명 - 2020.06.01 ~ 2021.02.28
    11. 대장암에서의 정맥침범 과정에서의 숙주 인자에 대한 연구 - 2020.01.01 ~ 2020.12.31
    12. KRAS 돌연변이와 miRNA 발현을 통한 췌장암 진단 패널개발 - 2019.09.25 ~ 2021.06.30
    13. 췌장암 검체의 상장간막동맥 절제연 세포를 이용한 췌장암 분자적 예후예측법 개발 - 2019.09.01 ~ 2020.08.31
    14. 췌장암 관련 miRNA 추출방법 및 프로머를 이용한 miRNA 바이오칩 검증 - 2019.06.26 ~ 2020.06.25
    15. 후성유전체 기법을 이용한 췌장 신경내분비종양의 진단 및 예후예측을 위한 바이오 마커 개발 - 2019.03.01 ~ 2019.05.31
    16. 후성유전체 기법을 이용한 췌장 신경내분비종양의 진단 및 예후예측을 위한 바이오 마커 개발 - 2018.04.01 ~ 2019.02.28
    17. 후성유전체 기법을 이용한 췌장 신경내분비종양의 진단 및 예후예측을 위한 바이오 마커 개발 - 2017.06.01 ~ 2018.03.31
    18. 환자유래 암 이식 마우스모델을 활용한 췌장암 치료항체의 효능 평가 - 2017.05.01 ~ 2017.12.31
    19. 후성유전체 기법을 이용한 췌장 신경내분비종양의 진단 및 예후예측을 위한 바이오 마커 개발 - 2016.06.01 ~ 2017.05.31
    20. 췌장암 절제 검체의 절제연에서 극초민감도의 디지털 PCR법을 이용한 췌장암 재발예측 바이오마커의 개발 - 2016.05.19 ~ 2020.12.31
    21. 환자유래 암 이식 마우스모델을 활용한 췌장암 치료항체의 효능 평가 - 2016.05.01 ~ 2017.04.30
    22. 췌장낭성종양의 조직 및 낭액으로부터 후성유전체 기법을 이용한 바이오마커의 개발 - 2015.05.01 ~ 2016.04.30
    23. 췌장암 수술환자의 절제연에서 초고민감도 돌연변이 발견기법을 이용한 췌장암 재발 바이오마커의 확립. - 2015.04.16 ~ 2020.12.31
    24. 췌장 신경내분비종양의 진단 및 예후예측을 위한 바이오 마커의 개발 - 2015.04.13 ~ 2025.12.31
    25. 췌장암 수술환자의 절제연에서 초고민감도 돌연변이 발견기법을 이용한 췌장암 재발 바이오마커의 확립 - 2015.01.01 ~ 2015.11.30
    26. 췌장 신경내분비종양의 진단 및 예후예측을 위한 바이오 마커의 개발 - 2015.01.01 ~ 2015.12.31
    27. 췌장암 수술환자의 절제연에서 초고민감도 돌연변이 발견기법을 이용한 췌장암 재발 바이오마커의 확립 - 2014.12.01 ~ 2014.12.31
    28. 소화기계 장기에서 발생한 신경내분비종에서의 호르몬 및 표적치료 단백의 발현과 임상양상과 예후의 연관성 - 2014.06.11 ~ 2020.12.31
    29. 간외담관암의 조기진단 및 예후예측을 위한 바이오 마커의 개발(3) - 2014.05.01 ~ 2015.05.31
    30. 췌장낭성종양의 조직 및 낭액으로부터 후성유전체 기법을 이용한 바이오마커의 개발 - 2014.05.01 ~ 2015.04.30
    31. 간외담관암의 조기진단 및 예후예측을 위한 바이오 마커의 개발(2) - 2013.05.01 ~ 2014.04.30
    32. 췌장낭성종양의 조직 및 낭액으로부터 후성유전체 기법을 이용한 바이오마커의 개발 - 2013.05.01 ~ 2014.04.30
    33. 소장암의 조기진단 및 표적치료인자의 개발 - 2013.01.01 ~ 2013.12.31
    34. 소장암의 조기진단 및 표적치료인자의 개발 - 2012.07.01 ~ 2013.12.31
    35. 간외담관암의 조기진단 및 예후예측을 위한 바이오 마커의 개발(1) - 2012.05.01 ~ 2013.04.30

    특허/기술이전실적

    1. 원위부 담도암의 침윤 깊이 측정 방법 및 이를 이용한 T 분류 판단 방법 - 2023.11.28
    2. 직장 신경내분비종양의 예후 예측 방법 - 2022.03.31
    3. 외과적 절제술을 받은 췌장암 환자의 재발 예측방법 - 2020.12.28

    국내외 경력

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