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  • 공경엽 교수

    병리학

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    전공분야

    유방병리, 내분비병리, 세포병리

    소속연구단

    관련/관심분야

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    주요논문

    1. Diagnostic Assessment of Deep Learning Algorithms for Frozen Tissue Section Analysis in Women with Breast Cancer [ Cancer Research and Treatment ] - 2023.04.01
    2. The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer [ CANCER RESEARCH AND TREATMENT ] - 2022.10.01
    3. Phenotypic Differences of CD103+ Tissue-Resident Memory T Cells Associated with Various Cancers [ PATHOBIOLOGY ] - 2022.03.01
    4. Prediction of prognostic signatures in triple-negative breast cancer based on the differential expression analysis via NanoString nCounter immune panel [ BMC CANCER ] - 2020.11.02
    5. Clinicopathological factors associated with tumor-infiltrating lymphocyte reactivity in breast cancer [ CANCER IMMUNOLOGY IMMUNOTHERAPY ] - 2020.11.01
    6. Challenge for Diagnostic Assessment of Deep Learning Algorithm for Metastases Classification in Sentinel Lymph Nodes on Frozen Tissue Section Digital Slides in Women with Breast Cancer [ CANCER RESEARCH AND TREATMENT ] - 2020.10.01
    7. T cell receptor repertoires of ex vivo-expanded tumor-infiltrating lymphocytes from breast cancer patients [ IMMUNOLOGIC RESEARCH ] - 2020.10.01
    8. Retained or altered expression of major histocompatibility complex class I in patient-derived xenograft models in breast cancer [ IMMUNOLOGIC RESEARCH ] - 2019.12.01
    9. Comparison of GenesWell BCT Score With Oncotype DX Recurrence Score for Risk Classification in Asian Women With Hormone Receptor-Positive, HER2-Negative Early Breast Cancer [ FRONTIERS IN ONCOLOGY ] - 2019.07.01
    10. Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis [ MODERN PATHOLOGY ] - 2019.01.01
    11. CD-11c-positive Dendritic cells in Triple -negative Breast Cancer [ IN VIVO ] - 2018.11.01
    12. Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer [ ONCOTARGET ] - 2017.12.26
    13. A new molecular prognostic score for predicting the risk of distant metastasis in patients with HR+/HER2- early breast cancer. [ SCIENTIFIC REPORTS ] - 2017.03.28
    14. Endoplasmic reticulum stress induces secretion of high-mobility group proteins and is associated with tumor-infiltrating lymphocytes in triple-negative breast cancer [ Oncotarget ] - 2016.09.13
    15. Differential expression of major histocompatibility complex class I in subtypes of breast cancer is associated with estrogen receptor and interferon signaling [ Oncotarget ] - 2016.05.24
    16. MxA expression is associated with tumor-infiltrating lymphocytes and is a prognostic factor in triple-negative breast cancer [ BREAST CANCER RESEARCH AND TREATMENT ] - 2016.04.13
    17. Expression of FOXM1 and related proteins in breast cancer molecular subtypes [ INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY ] - 2016.04.01
    18. Cytoplasmic expression of high mobility group B1 (HMGB1) is associated with tumor-infiltrating lymphocytes (TILs) in breast cancer. [ PATHOLOGY INTERNATIONAL ] - 2016.04.01
    19. High mobility group B1 and N1 (HMGB1 and HMGN1) are associated with tumor-infiltrating lymphocytes in HER2-positive breast cancers [ VIRCHOWS ARCHIV ] - 2015.12.01
    20. Expression of NY-ESO-1 in Triple-Negative Breast Cancer Is Associated with Tumor-Infiltrating Lymphocytes and a Good Prognosis [ ONCOLOGY ] - 2015.11.01
    21. Clinicopathologic Significance of the Intratumoral Heterogeneity of HER2 Gene Amplification in HER2-Positive Breast Cancer Patients Treated With Adjuvant Trastuzumab [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2015.10.01
    22. Comparison of Pathologic Response Evaluation Systems after Anthracycline with/without Taxane-Based Neoadjuvant Chemotherapy among Different Subtypes of Breast Cancers [ PLoS One ] - 2015.09.22
    23. Prognostic Significance of Tumor-Infiltrating Lymphocytes and the Tertiary Lymphoid Structures in HER2-Positive Breast Cancer Treated With Adjuvant Trastuzumab [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2015.08.01
    24. Prognostic and predictive value of NanoString-based immune-related gene signatures in a neoadjuvant setting of triple-negative breast cancer: relationship to tumor-infiltrating lymphocytes [ BREAST CANCER RESEARCH AND TREATMENT ] - 2015.06.01
    25. Autophagic Markers BECLIN 1 and LC3 are Associated with Prognosis of Multiple Myeloma. [ ACTA HAEMATOLOGICA ] - 2015.06.01
    26. Correlations between molecular subtypes and pathologic response patterns of breast cancers after neoadjuvant chemotherapy [ ANNALS OF SURGICAL ONCOLOGY ] - 2015.02.01
    27. Prognostic significance of the ratio of absolute neutrophil to lymphocyte counts for breast cancer patients with ER/PR-positivity and HER2-negativity in neoadjuvant setting [ TUMOR BIOLOGY ] - 2014.10.01
    28. MET expression is associated with disease-specific survival in breast cancer patients in the neoadjuvant setting [ PATHOLOGY RESEARCH AND PRACTICE ] - 2014.08.01
    29. Positive Expression of Insulin-Like Growth Factor-1 Receptor Is Associated with a Positive Hormone Receptor Status and a Favorable Prognosis in Breast Cancer [ 한국유방암학회지(Journal of Breast Cancer) ] - 2014.06.01
    30. Two histopathologically different diseases: hormone receptor-positive and hormone receptor-negative tumors in HER2-positive breast cancer [ BREAST CANCER RESEARCH AND TREATMENT ] - 2014.06.01
    31. Low prognostic implication of fibroblast growth factor family activation in triple-negative breast cancer subsets [ ANNALS OF SURGICAL ONCOLOGY ] - 2014.05.01
    32. Expression of lewis x is associated with poor prognosis in triple-negative breast cancer [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2013.06.01
    33. Sparganosis infection presenting as a palpable mass in male breast [ INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES ] - 2013.06.01
    34. Tumor-Associated Lymphocytes Predict Response to Neoadjuvant Chemotherapy in Breast Cancer Patients [ Journal of Breast Cancer ] - 2013.03.01
    35. Hormone Receptor Expression in Invasive Breast Cancer Among Korean Women and Comparison of 3 Antiestrogen Receptor Antibodies: A Multi-institutional Retrospective Study Using Tissue Microarrays [ AMERICAN JOURNAL OF SURGICAL PATHOLOGY ] - 2012.12.01
    36. HER2 Status by Standardized Immunohistochemistry and Silver-Enhanced In Situ Hybridization in Korean Breast Cancer [ Journal of Breast Cancer ] - 2012.12.01
    37. Outcome of "Atypical Squamous Cells" in Cervical Cytology: Follow-up Assessment by Loop Electrical Excision Procedure [ KOREAN JOURNAL OF PATHOLOGY ] - 2012.08.01
    38. The Ratio of Atypical Ductal Hyperplasia Foci to Core Numbers in Needle Biopsy: A Practical Index Predicting Breast Cancer in Subsequent Excision [ KOREAN JOURNAL OF PATHOLOGY ] - 2012.02.01
    39. Dual-color silver-enhanced in situ hybridization for assessing HER2 gene amplification in breast cancer [ MODERN PATHOLOGY ] - 2011.06.01
    40. Different prognostic significance of CD24 and CD44 expression in breast cancer according to hormone receptor status [ BREAST ] - 2011.02.01
    41. Detection of BRAF mutations in thyroid nodules by allele-specific PCR using a dual priming oligonucleotide system [ AMERICAN JOURNAL OF CLINICAL PATHOLOGY ] - 2010.05.01
    42. 유방으로 전이한 악성종양에 관한 분석 [ KOREAN JOURNAL OF PATHOLOGY ] - 2010.02.25
    43. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma [ CLINICAL ENDOCRINOLOGY ] - 2009.10.01
    44. cytomorphologic chagnes after ultrasonogram-guided percutaneous ethanol injection [ CYTOPATHOLOGY ] - 2009.06.01
    45. Analysis of leptomeningeal metastasis in cerebrospinal fluid cytology [ 대한병리학회지(The Korean Journal of Pathology) ] - 2009.02.01
    46. Cytomorphological changes after ultrasound-guided percutaneous ethanol injection in benign thyroid nodules. [ CYTOPATHOLOGY ] - 2008.05.09
    47. DNA Copy Number Changes in Thyroid Medullary Carcinomas Determined by Comparative Genomic Hybridization [ 대한병리학회 ] - 2008.02.01
    48. Thymic Metastasis in Breast Cancer: A Case Report. [ KOREAN JOURNAL OF RADIOLOGY ] - 2007.08.01
    49. Pure and mixed tubular carcinoma of the breast: Mammographic differential features. [ KOREAN JOURNAL OF RADIOLOGY ] - 2007.04.01
    50. 조직학적 악성소견을 보이는 소아부신피질종양; 1증례보고및 악성진단기준에 관한 고찰 [ 대한병리학회 ] - 2006.10.01
    51. Clinicopathologic significance of basal like subtype of breast cancer: a comparison with hormone receptor and Her-2/neu overexpressingphenotypes [ HUMAN PATHOLOGY ] - 2006.09.01
    52. The loss of p16 expression is strongly associated with hypermethylation-related inactivation in breast carcinoma [ ] - 2006.06.09
    53. 요 세포검사의 최근 검사기법 [ 대한세포병리학회지 ] - 2006.03.01
    54. Diagnostic utility of galectin-3 in aspirates of thyroid follicular lesions [ ACTA CYTOLOGICA ] - 2006.01.02
    55. A parotid mass with unusual cytological features [ CYTOPATHOLOGY ] - 2005.04.01
    56. Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland. A case report [ ACTA CYTOLOGICA ] - 2004.03.01
    57. Paragonimiasis of the breast: a case report of fine needle aspiration [ ACTA CYTOLOGICA ] - 2003.03.01

    연구과제 수주실적

    1. 면역 요법 증강을 위한 케모카인 매개성 T 세포 수송(trafficking) 연구 - 2022.03.01 ~ 2023.02.28
    2. 전신 요법 치료를 받는 TNBC 환자에서 PDL1의 발생률 및 역할을 평가하는 다국가 관찰 후향적 연구(VANESSA) - 2021.09.22 ~ 2023.03.31
    3. 병리 검사 이미지 데이터 구축 - 2021.05.01 ~ 2021.12.31
    4. (2020, 기본) 면역 요법 증강을 위한 케모카인 매개성 T 세포 수송(trafficking) 연구 - 2021.03.01 ~ 2022.02.28
    5. 유방암 환자를 대상으로 동반진단 의료기기(PNAClamp™ PIK3CA Mutation Detection Kit)의 유효성을 평가하기 위한 전향적, 동등성 비교 임상시험 - 2020.11.19 ~ 2023.12.31
    6. 고형암 종양침윤림프구 세포치료제 공정 개발 및 효능 평가를 위한 연구 - 2020.06.11 ~ 2025.05.31
    7. 면역 요법 증강을 위한 케모카인 매개성 T 세포 수송(trafficking) 연구 - 2020.06.01 ~ 2021.02.28
    8. 건강한 성인 자원자를 대상으로 고형암 종양침윤림프구 세포치료제 제조 공정 확립을 위한 연구 - 2020.05.28 ~ 2021.06.30
    9. 효과적인 면역치료제 개발을 위한 유방암의 수지상 세포의 분포와 기능 연구 - 2020.03.01 ~ 2020.05.31
    10. 인공지능 이미지 분석기술을 이용한 유방암 동결절편 진단 - 2020.02.20 ~ 2023.12.31
    11. GHO PATH Guide for hormone receptor positive breast cancer based on pathology images 개발 - 2020.01.15 ~ 2021.12.31
    12. ASAN 4T Trial의 성공적 IND 승인을 위한 TIL 생산 및 IND 자료 확보 - 2020.01.01 ~ 2020.12.31
    13. 유방암에서 NGS를 통한 neoantigen 발굴 및 artificial APC library 구축을 통한 neoantigen 특이적 T 림프구 규명 - 2020.01.01 ~ 2020.12.31
    14. 인공지능 이미지 분석기술을 이용한 관내유방암 환자의 수술 검체 병리 결과 예측 및 침윤성 유방암 환자의 수술 전 항암치료 감수성 예측 - 2019.04.25 ~ 2021.12.31
    15. ASAN 4T Trial의 성공적 IND 승인을 위한 TIL 생산 및 IND 자료 확보 - 2019.04.19 ~ 2019.12.31
    16. 유방암 항암치료 효능 예측 플랫폼 개발 - 2019.04.01 ~ 2020.03.31
    17. 효과적인 면역치료제 개발을 위한 유방암의 수지상 세포의 분포와 기능 연구 - 2019.03.01 ~ 2020.02.29
    18. 유방암에서 NGS를 통한 neoantigen 발굴 및 artificial APC library 구축을 통한 neoantigen 특이적 T 림프구 규명 - 2019.01.01 ~ 2019.12.31
    19. Public neoantigen 특이적 T 세포 수용체 규명 - 2019.01.01 ~ 2019.04.10
    20. 인공지능을 이용한 유방암 OncotypeDx 검사 결과 예측 시스템 개발 - 2018.08.09 ~ 2019.12.31
    21. 효과적인 면역치료제 개발을 위한 유방암의 수지상 세포의 분포와 기능 연구 - 2018.03.01 ~ 2019.02.28
    22. 종양 내 면역세포 구성 조합 및 면역관련 인자 발현 정도에 기반한 면역프로파일 분석 모델 개발 - 2018.01.01 ~ 2018.12.31
    23. 유방암에서 NGS를 통한 neoantigen 발굴 및 artificial APC library 구축을 통한 neoantigen 특이적 T 림프구 규명 - 2018.01.01 ~ 2018.12.31
    24. 유방암 환자 유래 종양조직모델 기반구축 및 적용 - 2017.09.07 ~ 2018.09.06
    25. 효과적인 면역치료제 개발을 위한 유방암의 수지상 세포의 분포와 기능 연구 - 2017.06.01 ~ 2018.02.28
    26. 한국인 Estrogen receptor 양성 유방암 환자의 유방암 예후 예측검사로서의 Curebest 95 Gene Classifier 유용성 평가 - 2017.02.27 ~ 2018.07.31
    27. Immune Monitoring Core 기반 구축 - 2017.01.01 ~ 2017.12.31
    28. 호르몬수용체 양성(ER+ 및/또는 PR+), 인간표피증식인자 수용체 음성(HER2-), 조기 유방암 여성 환자의 GenesWell™ BCT 검사 결과와 임상병리학적 지표 및 분자 유전학적 지표를 활용한 예후 인자와의 상관성 및 비교 분석을 평가하기 위한 단일기관, 비무작위배정, 후향적 - 2016.09.22 ~ 2017.09.01
    29. 유방암 환자 유래 종양조직모델 기반구축 및 적용 - 2016.09.07 ~ 2017.09.06
    30. 호르몬수용체 양성(ER+ 및/또는 PR+), 인간표피증식인자 수용체 음성(HER2-), pN0 또는 pN1 조기 유방암 여성 환자의 FFPE 잔여 검체(포르말린 고정 파라핀 포매 잔여 검체)를 대상으로 GenesWell™ BCT 검사법을 통한 유방암 예후 예측의 유효성을 평가하기 위한 후향적, 단 - 2016.08.10 ~ 2017.08.31
    31. 유방암 동물모델에서 종양으로 침윤한 림프구의 특징 연구 - 2016.01.01 ~ 2016.12.31
    32. 호르몬수용체 양성(ER+ 및/또는 PR+), 인간표피증식인자 수용체 음성(HER2-), pN0 또는 pN1 조기 유방암 여성 환자의 FFPE 잔여 검체(포르말린 고정 파라핀 포매 잔여 검체)를 대상으로 GenesWell™ BCT 검사법을 통한 유방암 예후 예측의 유효성을 평가하기 위한 후향적, 단 - 2015.10.13 ~ 2016.10.12
    33. 유방암 환자 유래 종양조직모델 기반구축 및 적용 - 2015.09.07 ~ 2016.09.06
    34. 유방암 면역 치료제 개발에 필요한 종양과 종양 주위 미세환경 분석 - 2015.04.29 ~ 2020.05.31
    35. 유방암에서 종양 면역 반응을 항진시키는 HMGN1의 세포 내외 이동과 항암제 혹은 방사선 감수성과의 관계 - 2015.01.01 ~ 2015.12.31
    36. 삼중음성 유방암의 선행항암화학 치료반응과 관련된 면역 인자 분석을 통한 새로운 치료표적 발굴 - 2014.01.01 ~ 2014.12.31
    37. 삼중음성 유방암의 선행항암화학 치료반응과 관련된 면역 인자와 miRNA 분석을 통한 새로운 치료표적 발굴 - 2013.09.30 ~ 2015.09.30
    38. 조기유방암환자의 임상시료 확보 및 Multiplex qPCR재검증 - 2013.04.01 ~ 2014.03.31

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