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  • 양석균 교수

    내과학

    패스워드가 일치하지 않습니다.

    전공분야

    대장질환, 염증성 장질환

    소속연구단

    관련/관심분야

        데이터가 없습니다.

    주요논문

    1. Changes in the Long-term Prognosis of Crohn's Disease between 1986 and 2015: The Population-Based Songpa-Kangdong Inflammatory Bowel Disease Cohort Study [ Gut and Liver ] - 2022.03.15
    2. Clinical Features and Long-Term Outcomes of Paediatric-Onset Inflammatory Bowel Disease in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea [ JOURNAL OF CROHNS & COLITIS ] - 2022.02.23
    3. Clinical Characteristics and Long-term Prognosis of Elderly-Onset Ulcerative Colitis in a Population-Based Cohort in the Songpa-Kangdong District of Seoul, Korea [ GUT AND LIVER ] - 2021.09.15
    4. Risk factors for rebleeding in Crohn's disease patients with acute severe lower gastrointestinal bleeding: With special reference to the role of anti-tumor necrosis factor therapy [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2021.09.01
    5. Clinical outcomes and long-term prognosis of perianal Crohn's disease in an Asian population [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2021.06.01
    6. Risk factors and prognostic value of acute severe lower gastrointestinal bleeding in Crohn's disease [ WORLD JOURNAL OF GASTROENTEROLOGY ] - 2021.05.21
    7. Safety and Optimal Timing of BCG Vaccination in Infants Born to Mothers Receiving Anti-TNF Therapy for Inflammatory Bowel Disease [ JOURNAL OF CROHNS COLITIS ] - 2020.12.01
    8. Long-term prognosis of ulcerative colitis and its temporal changes between 1986 and 2015 in a population-based cohort in the Songpa-Kangdong district of Seoul, Korea [ GUT ] - 2020.08.01
    9. Concordance regarding disease type and phenotypic characteristics among patients with familial inflammatory bowel disease [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2020.06.01
    10. Incidence and Outcomes of Perianal Disease in an Asian Population with Crohn's Disease: A Nationwide Population-Based Study [ DIGESTIVE DISEASES AND SCIENCES ] - 2020.04.01
    11. Clinical Implications of the CMV-Specific T-Cell Response and Local or Systemic CMV Viral Replication in Patients With Moderate to Severe Ulcerative Colitis [ Open Forum Infectious Diseases ] - 2019.12.18
    12. Association of TRAP1 with infliximab-induced mucosal healing in Crohn's disease [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2019.12.01
    13. A 30-year Trend Analysis in the Epidemiology of Inflammatory Bowel Disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015 [ JOURNAL OF CROHNS COLITIS ] - 2019.11.01
    14. Outcomes of ulcerative colitis-associated dysplasia patients referred for potential endoscopic submucosal dissection [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2019.09.01
    15. Incidence and clinical impact of perianal disease in patients with ulcerative colitis: A nationwide population-based study [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2019.06.01
    16. Development, validation, and application of a novel tool to measure disease-related knowledge in patients with inflammatory bowel disease [ KOREAN JOURNAL OF INTERNAL MEDICINE ] - 2019.01.01
    17. Increased Risk of Herpes Zoster Infection in Patients With Inflammatory Bowel Diseases in Korea [ CLINICAL GASTROENTEROLOGY AND HEPATOLOGY ] - 2018.12.01
    18. Amino acid position 37 of HLA-DRβ1 affects susceptibility to Crohn's disease in Asians. [ HUMAN MOLECULAR GENETICS ] - 2018.11.15
    19. An Intergenic Variant rs9268877 Between HLA-DRA and HLA-DRB Contributes to the Clinical Course and Long-term Outcome of Ulcerative Colitis [ JOURNAL OF CROHNS COLITIS ] - 2018.08.29
    20. Immunochip Meta-Analysis of Inflammatory Bowel Disease Identifies Three Novel Loci and Four Novel Associations in Previously Reported Loci [ JOURNAL OF CROHNS COLITIS ] - 2018.05.25
    21. Assessment of factors associated with smoking cessation at diagnosis or during follow-up of Crohn's disease [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2018.01.01
    22. X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans [ JOURNAL OF CROHNS COLITIS ] - 2017.07.01
    23. Clinical course of ulcerative colitis patients who develop acute pancreatitis [ WORLD JOURNAL OF GASTROENTEROLOGY ] - 2017.05.21
    24. Overall and cause-specific mortality in Korean patients with inflammatory bowel disease: A hospital-based cohort study [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2017.04.01
    25. Underestimation of smoking rates in an East Asian population with Crohn's disease [ Gut and Liver ] - 2017.01.15
    26. Physicians Should Provide Shared Decision-Making for Anti-TNF Therapy to Inflammatory Bowel Disease Patients [ JOURNAL OF KOREAN MEDICAL SCIENCE ] - 2017.01.01
    27. Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans. [ GASTROENTEROLOGY ] - 2016.12.01
    28. Influence of a Positive Family History on the Clinical Course of Inflammatory Bowel Disease [ Journal of Crohns & Colitis ] - 2016.09.01
    29. Change in the diagnosis of inflammatory bowel disease: a hospital-based cohort study from Korea [ Intestinal Research ] - 2016.07.01
    30. Long-Term Outcomes of Infliximab Treatment in 582 Korean Patients with Crohn’s Disease: A Hospital-Based Cohort Study [ DIGESTIVE DISEASES AND SCIENCES ] - 2016.07.01
    31. Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease. [ SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY ] - 2016.06.15
    32. Personalizing IBD Therapy: The Asian Perspective [ DIGESTIVE DISEASES ] - 2016.05.16
    33. Risk Factors and Clinical Outcomes Associated with Cytomegalovirus Colitis in Patients with Acute Severe Ulcerative Colitis [ INFLAMMATORY BOWEL DISEASES ] - 2016.04.01
    34. Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis through Immunochip Analysis in Koreans. [ INFLAMMATORY BOWEL DISEASES ] - 2016.01.15
    35. Six Cases of Lung Injury Following Anti-tumour Necrosis Factor Therapy for Inflammatory Bowel Disease [ Journal of Crohns & Colitis ] - 2015.11.01
    36. Short- and Long-Term Outcomes of Acute Severe Ulcerative Colitis in Korea: The 1999-2005 Cohort [ INFLAMMATORY BOWEL DISEASES ] - 2015.08.01
    37. ATG16L1 contributes to Crohn's disease susceptibility in Koreans: overmuch concern for ethnic difference? [ GUT ] - 2015.04.15
    38. Appendectomy and the clinical course of ulcerative colitis: A retrospective cohort study and a nested case-control study from Korea [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2015.03.01
    39. The risk of colorectal cancer in inflammatory bowel disease: a hospital-based cohort study from Korea [ SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY ] - 2015.02.01
    40. Long-term Prognosis of Ulcerative Colitis and its Temporal Change Between 1977 and 2013: A Hospital-based Cohort Study from Korea [ Journal of Crohns & Colitis ] - 2015.02.01
    41. Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. [ INFLAMMATORY BOWEL DISEASES ] - 2015.01.02
    42. Usefulness of C-reactive protein as a disease activity marker in Crohn's disease according to the location of disease [ Gut and Liver ] - 2015.01.01
    43. TNFSF15 is an independent predictor for the development of Crohn's disease-related complications in Koreans [ Journal of Crohns & Colitis ] - 2014.10.01
    44. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia [ NATURE GENETICS ] - 2014.09.10
    45. Appendiceal Skip Inflammation and Ulcerative Colitis [ DIGESTIVE DISEASES AND SCIENCES ] - 2014.09.01
    46. Long-term Prognosis of Crohn's Disease and Its Temporal Change Between 1981 and 2012: A Hospital-based Cohort Study from Korea [ INFLAMMATORY BOWEL DISEASES ] - 2014.03.01
    47. Atypical distribution of inflammation in newly diagnosed ulcerative colitis is not rare [ CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2014.03.01
    48. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. [ GUT ] - 2014.01.01
    49. Efficacy of hepatitis a vaccination and factors impacting on seroconversion in patients with inflammatory bowel disease [ INFLAMMATORY BOWEL DISEASES ] - 2014.01.01
    50. Severe disease activity and cytomegalovirus colitis are predictive of a nonresponse to infliximab in patients with ulcerative colitis [ DIGESTIVE DISEASES AND SCIENCES ] - 2013.12.01
    51. The long-term efficacy of azathioprine in steroid-dependent ulcerative colitis [ SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY ] - 2013.12.01
    52. Long-term prognosis of the jejunal involvement of Crohn's disease [ JOURNAL OF CLINICAL GASTROENTEROLOGY ] - 2013.05.31
    53. Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians. [ INFLAMMATORY BOWEL DISEASES ] - 2013.04.01
    54. Clinical courses of chronic hepatitis B virus infection and inflammatory bowel disease in patients with both diseases [ INFLAMMATORY BOWEL DISEASES ] - 2012.11.01
    55. Risk factors and outcome of acute severe lower gastrointestinal bleeding in Crohn's disease [ DIGESTIVE AND LIVER DISEASE ] - 2012.09.01
    56. Diagnostic sensitivity of culture and drug resistance patterns in Korean patients with intestinal tuberculosis [ INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE ] - 2012.06.01
    57. 크론병 치료 가이드라인 [ 대한소화기학회지 ] - 2012.02.01
    58. Long-term outcome of cap polyposis, with special reference to the effects of steroid therapy [ GASTROINTESTINAL ENDOSCOPY ] - 2012.01.01
    59. Long term follow-up of appendiceal and distal right-sided colonic inflammation [ ENDOSCOPY ] - 2012.01.01
    60. Association of FCGR2A, JAK2 or HNF4A variants with ulcerative colitis in Koreans [ DIGESTIVE AND LIVER DISEASE ] - 2011.11.01
    61. Clinical Characteristics of Ulcerative Colitis Associated with Primary Sclerosing Cholangitis in Korea [ INFLAMMATORY BOWEL DISEASES ] - 2011.09.01
    62. Colonoscopic findings and histologic diagnostic yield of colorectal endometriosis [ JOURNAL OF CLINICAL GASTROENTEROLOGY ] - 2011.07.01
    63. Prospective evaluation of the clinical utility of interferon-γ assay in the differential diagnosis of intestinal tuberculosis and Crohn's disease [ INFLAMMATORY BOWEL DISEASES ] - 2011.06.01
    64. No association between TNFSF15 and IL23R with ulcerative colitis in Koreans. [ JOURNAL OF HUMAN GENETICS ] - 2011.03.15
    65. Association of CARD8 with inflammatory bowel disease in Koreans. [ JOURNAL OF HUMAN GENETICS ] - 2011.03.15
    66. Isolated terminal ileal ulcerations in asymptomatic individuals: natural course and clinical significance [ GASTROINTESTINAL ENDOSCOPY ] - 2010.12.01
    67. Clinical features and long-term prognosis of Crohn's disease in Korea [ SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY ] - 2010.10.01
    68. Association of toll-like receptor gene with crohns disease in koreans [ 대한소화기학회 ] - 2009.12.01
    69. Prospective randomized trial of six-month versus nine-month therapy for intestinal tuberculosis [ ANTIMICROBIAL AGENTS AND CHEMOTHERAPY ] - 2009.10.01
    70. Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans [ INFLAMMATORY BOWEL DISEASES ] - 2009.09.01
    71. 한국인 크론병에 대한 Infliximab의 효과 [ 대한소화기학회지 ] - 2009.08.01
    72. 한국인 크론병 환자에서 Azathioprine/6-Mercaptopurine 치료의 안전성과 유용성 [ Intestinal research ] - 2009.06.01
    73. 크론병 진단 가이드라인 [ 대한소화기학회지 ] - 2009.03.01
    74. Clinical features predicting the detection of abnormalities by double balloon endoscopy in patients with suspected small bowel bleeding. [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2008.07.01
    75. Association of TNFSF15 with Crohn's disease in Koreans. [ AMERICAN JOURNAL OF GASTROENTEROLOGY ] - 2008.06.15
    76. Epidemiology of inflammatory bowel disease in the Songpa-Kangdong district, Seoul, Korea, 1986-2005: a KASID study. [ INFLAMMATORY BOWEL DISEASES ] - 2008.04.01
    77. Antitumor necrosis factor-alpha therapy for early postoperative recurrence of gastrointestinal Behcet's disease: report of a case [ DISEASES OF THE COLON & RECTUM ] - 2007.05.01
    78. Clinical features and natural history of ulcerative colitis in Korea [ INFLAMMATORY BOWEL DISEASES ] - 2007.03.01
    79. Familial occurrence of inflammatory bowel disease: a Korean study [ INFLAMMATORY BOWEL DISEASES ] - 2006.12.01
    80. Analysis of Colonoscopic Findings in the Differential Diagnosis Between Intestinal Tuberculosis and Crohn's Disease [ ENDOSCOPY ] - 2006.04.01
    81. Clinical usefulness of telomerase for the detection of colon cancer in ulcerative colitis patients [ JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY ] - 2005.10.01
    82. 대장의 점막하 침윤암의 심달도와 림프절 전이에 따른 기질단백분해효소와 억제인자의 발현 및 신생혈관 형성 [ 대한소화기학회 ] - 2005.06.01
    83. Clinical course of distal ulcerative colitis in relation to appendiceal orifice inflammation status [ INFLAMMATORY BOWEL DISEASES ] - 2005.04.14
    84. 장결핵의 진단을 위한 대장내시경 생검과 장외결핵의 유용성 [ 대한소화기학회지 ] - 2004.09.01
    85. Atypical endoscopic features of rectal carcinoids [ ENDOSCOPY ] - 2004.03.01
    86. 한국인 크론병의 진단시 임상 양상과 경과 [ 대한소화기학회지 ] - 2004.01.01
    87. Clinicopathologic features of ileocolonic malignant lymphoma:analysis according to colonoscopic classification [ GASTROINTESTINAL ENDOSCOPY ] - 2003.03.30
    88. Clinicopathological Features of Malignant Lymphoma Discovered by Colonoscopy: An Analysis According to Endoscopic Classification [ GASTROINTESTINAL ENDOSCOPY ] - 2003.03.01

    연구과제 수주실적

    1. 염증성 장질환 환자의 정상적인 삶 및 질병 부담에 대한 인식: 국제 다기관 연구 - 2019.10.07 ~ 2022.12.31
    2. 한국인 크론병의 발병기전 임상적 및 유전적 특성 규명과 새로운 바이오마커 및 치료제 개발 - 2017.04.10 ~ 2018.03.31
    3. 궤양성 대장염 및 크론병에서 Entyvio(베돌리주맙 IV)의 연장 사용 시험 (Extended Access Program) - 2016.08.08 ~ 2021.12.31
    4. 한국인 크론병의 임상특성, 예후인자 및 유전체 바이오마커 발굴 - 2016.04.01 ~ 2017.03.31
    5. 염증성 장질환 환자에서의 새로운 히스톤 탈아세틸화 효소 6 억제제 치료 효과 연구 - 2015.11.02 ~ 2016.09.30
    6. KSTHD_FURESTEM-CD 제 1/2a상 임상시험에 참여하여 퓨어스템-시디주를 한번이라도 투여 받은 경험이 있는 중등도 활동성 크론병 환자를 대상으로 퓨어스템-시디주(FURESTEM-CD Inj.)의 장기 안전성 및 유효성을 평가하기 위한 공개, 단일기관, 연장연구 - 2015.10.19 ~ 2020.08.10
    7. 중등증 내지 중증의 활동성 궤양성 대장염 시험대상자들에서 우스테키누맙 유도 및 유지요법의 안전성과 유효성을 평가하는 제3상, 무작위 배정, 이중 눈가림, 위약 대조, 병행군, 다기관 임상시험 - 2015.09.17 ~ 2022.01.31
    8. 염증성 장질환 환자에서 SHC1 유전자가 T 세포 발생에 미치는 영향 - 2015.09.03 ~ 2017.08.31
    9. 한국인 크론병의 임상특성, 예후인자 및 유전체 바이오마커 발굴 - 2015.04.01 ~ 2016.03.31
    10. 중등도 활동성 크론병 환자를 대상으로 퓨어스템-시디주(FURESTEM-CD Inj.)의 안전성 및 유효성 평가를 위한 공개, 단일기관, 비교, 제 1/2a상 임상시험 - 2014.07.24 ~ 2016.07.31
    11. 한국인 크론병의 발병기전, 임상적 및 유전적 특성 규명과 새로운 바이오마커 및 치료제 개발 - 2014.04.01 ~ 2015.03.31
    12. 크론병 피험자에서 PF-00547659 의 장기 안전성을 평가하는 다기관 공개 연장 시험 (OPERA II) - 2013.06.17 ~ 2019.08.31
    13. 궤양성 대장염 피험자에서 PF-00547659의 장기 안전성을 평가하는 다기관 공개 연장 연구(TURANDOT II) - 2013.05.27 ~ 2018.12.31
    14. 중등증에서 중증의 궤양성 대장염 피험자들에서 PF-00547659의 유효성과 안전성을 평가하는 이중 눈가림, 무작위 배정, 위약 대조, 평행군, 용량 범위 결정 연구 (TURANDOT) - 2013.04.15 ~ 2018.03.31
    15. 크론병 피험자에서 PF-00547659 의 유효성과 안전성을 평가하는 이중 눈가림, 무작위배정, 위약 대조, 용량-범위결정 시험 (OPERA) - 2013.04.12 ~ 2017.04.30
    16. 한국인 크론병의 임상특성, 예후인자 및 유전체 바이오마커 발굴 - 2013.04.01 ~ 2014.03.31
    17. 아달리무맙 유도요법을 받는 중등도에서 중증의 크론병의 경과를 관찰하는 임상 검사로써 대변 칼프로텍틴에 대한 관찰연구 - 2012.12.07 ~ 2014.03.31
    18. 한국인 염증성 장질환의 역학: 송파구-강동구 인구기반 코호트 연구 - 2012.08.31 ~ 2018.06.30
    19. ALIGN - 만성 염증성 질환에서 약물 복용에 대한 환자 일반적 및 특이적 신념과 전신성 투여 요법에 대한 순응도를 파악하기 위한 다국가, 단면 연구 - 2012.08.10 ~ 2013.09.30
    20. 중등증에서 중증의 크론병 피험자에서 BMS-945429의 유도요법 및 유지요법의 임상적 유효성과 안전성을 평가하는 제 2b상, 이중눈가림, 무작위배정, 위약 대조, 이중 위약, 용량 범위 시험 - 2012.08.03 ~ 2016.05.30
    21. 궤양성 대장염 피험자에서 경구 CP-690,550의 유지 치료(Maintenance Therapy)에 대한 다기관, 무작위 배정, 이중 눈가림, 위약 대조, 병행 그룹 임상시험 - 2012.07.23 ~ 2016.12.05
    22. 중등도에서 중증의 궤양성 대장염 피험자에서 경구 CP-690,550 의 다기관,공개(OPEN-LABEL) 임상시험 - 2012.07.23 ~ 2016.08.05
    23. 크론병 환자에서 유지 요법으로서 CP-690,550의 공개군 연장 시험 - 2012.07.16 ~ 2015.02.28
    24. 한국인 크론병의 임상특성, 예후인자 및 유전체 바이오마커 발굴 - 2012.05.01 ~ 2013.03.31
    25. 중등증에서 중증 크론병 피험자의 유지 치료로서 CP-690,550의 안전성 및 유효성을 평가하기 위한 무작위배정, 이중 눈가림, 위약 대조, 평행군, 다기관 임상 시험 - 2012.03.30 ~ 2014.02.28
    26. 중등도에서 중증의 궤양성 대장염 피험자에서 경구 CP-690,550 의 유도치료 (Induction Therapy)에 대한, 다기관, 무작위배정, 이중 눈가림, 위약 대조, 병행 그룹 임상시험 - 2012.03.26 ~ 2015.12.05
    27. 중등도에서 중증 활성의 크론병이 있는 피험자에서 GSK1605786A에 의한 임상적 반응 및/또는 관해를 유도하기 위한 무작위 배정, 이중 눈가림, 활성 치료 임상시험 - 2012.02.03 ~ 2013.10.31
    28. 중등증에서 중증 크론병 피험자의 유도 치료로서 CP-690,550의 안전성 및 유효성을 평가하기 위한 무작위배정, 이중 눈가림, 위약 대조, 평행군, 다기관 임상 시험 - 2012.02.01 ~ 2013.06.13
    29. 크론병 피험자의 관해 유지에서 GSK1605786A의 유효성 및 안전성을 조사하기 위한 52주 무작위 배정, 이중 눈가림, 위약 대조 임상시험 - 2012.01.16 ~ 2014.09.30
    30. 크론병이 있는 피험자에서 GSK1605786A의 안전성을 평가하기 위한 라벨-공개 연장시험 - 2012.01.16 ~ 2015.09.30

    특허/기술이전실적

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    국내외 경력

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