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  • 김용길 교수

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    류마티스 질환

    소속연구단

    근골격계 연구단

    관련/관심분야

        데이터가 없습니다.

    주요논문

    1. Effect of belimumab in patients with systemic lupus erythematosus treated with low dose or no corticosteroids [ KOREAN JOURNAL OF INTERNAL MEDICINE ] - 2024.03.01
    2. The Expression of the Alpha7 Nicotinic Acetylcholine Receptor and the Effect of Smoking in Curdlan-Administered SKG Mice [ Biomedicines ] - 2023.10.11
    3. Urine SERPINC1/ORM1 as biomarkers for early detection of lupus nephritis in MRL-lpr mice [ Frontiers in immunology ] - 2023.09.08
    4. Subchondral insufficiency fracture of the femoral head in a patient with ankylosing spondylitis: Case report and literature review [ International Journal of Rheumatic Diseases ] - 2023.08.01
    5. Disease course of non-radiographic axial spondyloarthritis: Data from a long-term retrospective observational cohort [ PLoS One ] - 2023.06.30
    6. Anti-S1/RBD-Specific Antibody Formation After SARS-CoV-2 Vaccination in Elderly Rheumatoid Arthritis Patients: Single-Center Prospective Observational Study [ JOURNAL OF KOREAN MEDICAL SCIENCE ] - 2023.04.10
    7. Serum IgG4 level during initial treatment as a predictor of relapse in IgG4-related disease [ PLoS One ] - 2023.03.09
    8. Dysfunction in parkin aggravates inflammatory bone erosion by reinforcing osteoclast activity [ Cell and Bioscience ] - 2023.03.07
    9. Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A-RUNX2 pathway [ JOURNAL OF CELLULAR AND MOLECULAR MEDICINE ] - 2023.03.01
    10. Incidence of rheumatic diseases during the COVID-19 pandemic in South Korea [ The Korean Journal of Internal Medicine ] - 2023.03.01
    11. Interleukin-32 as a biomarker in rheumatic diseases: A narrative review [ Frontiers in immunology ] - 2023.02.15
    12. Correlation between serologic parameters and disease activity of IgG4-related disease: Differences between patients with normal and elevated serum IgG4 concentrations [ Frontiers in immunology ] - 2022.10.12
    13. Predictive Factors for Rheumatoid Arthritis Flare After Switching From Intravenous to Subcutaneous Formulation of Tocilizumab in Real- World Practice [ JOURNAL OF KOREAN MEDICAL SCIENCE ] - 2022.05.01
    14. Macrophage activation syndrome in rheumatic disease: Clinical characteristics and prognosis of 20 adult patients [ PLOS ONE ] - 2022.05.01
    15. Risk of New-Onset Diabetes Mellitus Associated with Antirheumatic Drugs in Patients with Rheumatoid Arthritis: A Nationwide Population Study [ JOURNAL OF CLINICAL MEDICINE ] - 2022.04.01
    16. Comparison of the Seven Interleukin-32 Isoforms' Biological Activities: IL-32θ Possesses the Most Dominant Biological Activity [ Frontiers in immunology ] - 2022.02.01
    17. The Value of Thermal Imaging for Knee Arthritis: A Single-Center Observational Study [ YONSEI MEDICAL JOURNAL ] - 2022.02.01
    18. Risk of Acute Anterior Uveitis in Ankylosing Spondylitis According to the Type of Tumor Necrosis Factor-Alpha Inhibitor and History of Uveitis: A Nationwide Population-Based Study [ Journal of clinical medicine ] - 2022.01.01
    19. Comparative efficacy of low-dose versus regular-dose colchicine to prevent flares in gout patients initiated on urate-lowering therapies [ RHEUMATOLOGY ] - 2021.12.24
    20. Anaphylaxis to tocilizumab in patients with rheumatic disease [ IMMUNOTHERAPY ] - 2021.12.01
    21. Discovery of urine biomarkers for lupus nephritis via quantitative and comparative proteome analysis [ CLINICAL AND TRANSLATIONAL MEDICINE ] - 2021.11.01
    22. Risk of Cancer in Middle-aged Patients With Gout: A Nationwide Population-based Study in Korea [ JOURNAL OF RHEUMATOLOGY ] - 2021.09.01
    23. Acetylated Diacylglycerol 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol in Autoimmune Arthritis and Interstitial Lung Disease in SKG Mice [ BIOMEDICINES ] - 2021.08.27
    24. Urine beta-2-glycoprotein 1 as a biomarker for diagnosis of systemic lupus erythematosus [ LUPUS ] - 2021.07.01
    25. Pregnancy outcomes in Korean women with ankylosing spondylitis [ KOREAN JOURNAL OF INTERNAL MEDICINE ] - 2021.05.01
    26. Anti-tumor necrosis factor-induced lupus in patients with inflammatory bowel disease: a hospital-based cohort study from Korea [ THERAPEUTIC ADVANCES IN GASTROENTEROLOGY ] - 2021.03.01
    27. Treatment Response to Idiopathic Retroperitoneal Fibrosis-associated Hydronephrosis With a Focus on IgG4/IgG3 Serum Concentration Ratio [ 대한류마티스학회지 ] - 2021.01.01
    28. Autoantibodies against Protein Phosphatase Magnesium-Dependent 1A as a Biomarker for Predicting Radiographic Progression in Ankylosing Spondylitis Treated with Anti-Tumor Necrosis Factor Agents [ JOURNAL OF CLINICAL MEDICINE ] - 2020.12.01
    29. Prognostic factors for steroid-free remission in patients with idiopathic inflammatory myopathies: importance of anthropometric measurements [ THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE ] - 2020.10.01
    30. Early discontinuation of tofacitinib in patients with rheumatoid arthritis co-treated with rifampin for latent tuberculosis [ JOINT BONE SPINE ] - 2020.10.01
    31. Effect of Vitamin D Supplementation on Bone Mineral Density in Rheumatoid Arthritis Patients With Osteoporosis [ Frontiers in medicine ] - 2020.08.21
    32. Effects of Dihydrotestosterone on Osteoblast Activity in Curdlan-Administered SKG Mice and Osteoprogenitor Cells in Patients With Ankylosing Spondylitis [ ARTHRITIS RESEARCH & THERAPY ] - 2020.05.24
    33. Plasma immunoglobulin binding protein 1 as a predictor of development of lupus nephritis [ LUPUS ] - 2020.05.01
    34. Negative Regulation of Osteoclast Commitment by Intracellular Protein Phosphatase Magnesium-Dependent 1A [ ARTHRITIS RHEUMATOLOGY ] - 2020.05.01
    35. Reasons for the High Cesarean Delivery Rate among Women with Ankylosing Spondylitis: Using the Korean National Health Insurance Database [ JOURNAL OF RHEUMATOLOGY ] - 2020.05.01
    36. Liver enzyme elevation in patients with ankylosing spondylitis treated with tumor necrosis factor inhibitors: a single-center historical cohort study [ KOREAN JOURNAL OF INTERNAL MEDICINE ] - 2020.05.01
    37. Factors associated with aggravation of tubulointerstitial damage on repeated biopsies in lupus nephritis patients with treatment failure [ CLINICAL AND EXPERIMENTAL RHEUMATOLOGY ] - 2020.03.01
    38. Renal flare in class V lupus nephritis: increased risk in patients with tubulointerstitial lesions [ RHEUMATOLOGY INTERNATIONAL ] - 2019.12.01
    39. Effect of tumor necrosis factor inhibition on spinal inflammation and spinal ankylosis in SKG mice [ SCIENTIFIC REPORTS ] - 2019.11.29
    40. Effects of Pregnancy and Delivery Methods on Change in Ankylosing Spondylitis Treatment Using the Korean Health Insurance Review and Assessment Service Claims Database. [ JOURNAL OF KOREAN MEDICAL SCIENCE ] - 2019.09.30
    41. Conventional synthetic disease-modifying antirheumatic drugs and bone mineral density in rheumatoid arthritis patients with osteoporosis: possible beneficial effect of leflunomide. [ CLINICAL AND EXPERIMENTAL RHEUMATOLOGY ] - 2019.09.30
    42. Statins reduce relapse rate in Takayasu arteritis [ INTERNATIONAL JOURNAL OF CARDIOLOGY ] - 2019.07.15
    43. Tocilizumab-induced Thrombocytopenia in Patients with Rheumatoid Arthritis [ 대한류마티스학회지 ] - 2019.07.03
    44. Interleukin-32γ: Possible association with the activity and development of nephritis in patients with systemic lupus erythematosus. [ International Journal of Rheumatic Diseases ] - 2019.07.01
    45. Reply to: Challenging therapeutic goal in large vessel vasculitis [ INTERNATIONAL JOURNAL OF CARDIOLOGY ] - 2019.07.01
    46. Immunoglobulin Binding Protein 1 as a Potential Urine Biomarker in Patients with Lupus Nephritis [ INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ] - 2019.05.27
    47. Prefoldin 5 and Anti-prefoldin 5 Antibodies as Biomarkers for Uveitis in Ankylosing Spondylitis [ FRONTIERS IN IMMUNOLOGY ] - 2019.03.01
    48. 크론병에서 인플릭시맵 투약 후 발생한 전신홍반루푸스 1예 [ 대한내과학회지 ] - 2019.03.01
    49. In-stent Restenosis after Drug-eluting Stent Implantation in Rheumatoid Arthritis: Possible Protective Effect of Methotrexate. [ JOURNAL OF RHEUMATOLOGY ] - 2018.08.01
    50. Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis [ ARTHRITIS RESEARCH THERAPY ] - 2018.07.11
    51. IL-17A(+)GM-CSF+ Neutrophils Are the Major Infiltrating Cells in Interstitial Lung Disease in an Autoimmune Arthritis Model [ FRONTIERS IN IMMUNOLOGY ] - 2018.07.02
    52. Role of IL-32 Gamma on Bone Metabolism in Autoimmune Arthritis [ IMMUNE NETWORK ] - 2018.06.09
    53. Reduction or cessation of antiviral agents in hepatitis B virus carriers treated with biologic agents [ CLINICAL AND EXPERIMENTAL RHEUMATOLOGY ] - 2018.01.05
    54. The risk of herpes zoster in patients with ankylosing spondylitis: Analysis of the Korean National Health Insurance Service - Sample cohort database [ MODERN RHEUMATOLOGY ] - 2018.01.01
    55. Nontuberculous mycobacterial infection in rheumatoid arthritis patients: a single-center experience in South Korea. [ The Korean Journal of Internal Medicine ] - 2017.11.01
    56. Association between Treatment with Biologic Agents and the Incidence of Herpes Zoster in Rheumatoid Arthritis [ 대한류마티스학회지 ] - 2017.10.01
    57. Ileocolonoscopic findings in patients with ankylosing spondylitis: a single center retrospective study [ The Korean Journal of Internal Medicine ] - 2017.09.01
    58. Neutrophil-to-lymphocyte ratio is a reliable marker of treatment response in rheumatoid arthritis patients during tocilizumab therapy [ Modern Rheumatology ] - 2017.05.01
    59. Interleukin-32 Gamma Stimulates Bone Formation by Increasing miR-29a in Osteoblastic Cells and Prevents the Development of Osteoporosis [ SCIENTIFIC REPORTS ] - 2017.01.12
    60. Clinical outcomes of hydronephrosis in patients with systemic lupus erythematosus [ International Journal of Rheumatic Diseases ] - 2016.12.01
    61. Immunoglobulin G Levels as a Prognostic Factor for Autoimmune Hepatitis Combined With Systemic Lupus Erythematosus. [ ARTHRITIS CARE & RESEARCH ] - 2016.07.01
    62. Safety of Resuming Tumor Necrosis Factor Inhibitors in Ankylosing Spondylitis Patients Concomitant with the Treatment of Active Tuberculosis: A Retrospective Nationwide Registry of the Korean Society of Spondyloarthritis Research. [ PLoS One ] - 2016.04.21
    63. High level of interleukin-32 gamma in the joint of ankylosing spondylitis is associated with osteoblast differentiation. [ ARTHRITIS RESEARCH & THERAPY ] - 2015.12.04
    64. Factors related to outcomes in lupus-related protein-losing enteropathy. [ The Korean Journal of Internal Medicine ] - 2015.11.02
    65. The Incidence of Uveitis in Ankylosing Spondylitis Patients Undergoing Tumor Necrosis Factor Inhibiting Therapy in Korea [ 대한류마티스학회지 ] - 2015.10.01
    66. 전신홍반루푸스에 동반된 불응성 혈구포식 림프조직구증식증에서Tocilizumab 치료 1예 [ 대한내과학회지 ] - 2015.09.01
    67. Role of PPM1A and anti-PPM1A Autoantibodies in Ankylosing Spondylitis [ ARTHRITIS AND RHEUMATISM ] - 2014.10.01
    68. Safety of resuming tumour necrosis factor inhibitors in patients who developed tuberculosis as a complication of previous TNF inhibitors [ RHEUMATOLOGY ] - 2014.08.01
    69. 류마티스 다발근통의 진단과 치료 [ 대한내과학회지 ] - 2014.05.01
    70. The effect of various disease-modifying anti-rheumatic drugs on the suppressive function of CD4(+)CD25(+) regulatory T cells [ RHEUMATOLOGY INTERNATIONAL ] - 2013.02.01
    71. Elevated interleukin 32 expression in granulomatosis with polyangiitis. [ RHEUMATOLOGY ] - 2012.11.01
    72. The Influence of Interleukin-32γ on Osteoclastogenesis with a Focus on Fusion-Related Genes [ JOURNAL OF CLINICAL IMMUNOLOGY ] - 2012.02.01
    73. Inflammatory and Noninflammatory Vascular Disease Causing Hemobilia [ JCR-JOURNAL OF CLINICAL RHEUMATOLOGY ] - 2011.04.01
    74. 류마티스관절염에 동반된 ANCA 관련 불충분-면역성 사구체신염 2예 [ 대한류마티스학회지 ] - 2010.09.01
    75. 전선 홍반 루푸스의 치료 [ 대한내과학회지 ] - 2010.07.01
    76. Effect of Interleukin-32r on Differentiation of Osteoclasts From CD14+ Monocytes [ ARTHRITIS AND RHEUMATISM ] - 2010.02.01
    77. Serum cholesterol in idiopathic and lupus-related protein-losing enteropathy [ LUPUS ] - 2008.06.02
    78. The difference between lupus nephritis class IV-G and IV-S in Koreans: focus on the response to cyclophosphamide induction treatment. [ RHEUMATOLOGY ] - 2008.06.01

    연구과제 수주실적

    1. 활성 건선성 관절염이 있는 시험대상자를 대상으로 징후 및 증상을 개선하고 방사선학적 진행을 억제함에 있어 피하 투여 구셀쿠맙의 유효성 및 안전성을 평가하는 제3b상, 다기관, 무작위배정, 이중눈가림, 위약 대조 임상시험. - 2022.12.12 ~ 2027.02.28
    2. 실세계 데이터에 기반한 강직성 척추염 환자의 임상적 특성 및 치료 현황 분석 - 2022.09.22 ~ 2023.12.31
    3. 건강한 기증자의 혈액유래 자연살해세포를 이용한 세포치료제 제조공정 개발 연구 - 2022.07.07 ~ 2023.07.31
    4. 급성 전방 포도막염 병력이 있는 강직성 척추염환자에서 인플릭시맙 또는 아달리무맙 피하주사로 치료받는 환자의 급성 전방 포도막염 재발률 비교 평가 - 2022.04.07 ~ 2024.04.01
    5. 생물학적 및_또는 표적 합성 질병조절항류마티스제(Biologic and_or Targeted Synthetic Disease-Modifying Anti-Rheumatic Drug, b_tsDMARD)에 불충분한 반응을 보이는 중등증 내지 중증의 활성 류마티스 관절염 환자를 대상으로 ABBV-154의 안전성과 유효성을 평가하기 위 - 2022.02.16 ~ 2024.05.09
    6. 바이오 Core Facility 구축 사업 - 2022.01.01 ~ 2022.12.31
    7. MRG102의 류마티스 관절염 및 통풍에서의 바이오마커로서의 활용 가능성 평가 연구 - 2021.09.16 ~ 2022.08.31
    8. 바이오 Core Facility 구축 사업 - 2021.04.01 ~ 2021.12.31
    9. 강직척추염 환자의 척추강직 관련 바이오마커 개발 연구 - 2021.03.01 ~ 2022.02.28
    10. 류마티스 질환 정밀의료 코호트 구축 - 2021.01.01 ~ 2021.12.31
    11. 마우스 모델을 이용한 프로게스테론 유도 단백질 PIBF1의 류마티스관절염 발생 억제 효능 평가 - 2021.01.01 ~ 2021.12.31
    12. 강직성 척추염에서 TNF 억제제를 투여 시작하는 환자에서 급성 앞포도막염 발생 한국 전국 청구 자료 분석 - 2020.08.18 ~ 2022.11.30
    13. 강직척추염 환자의 척추강직 관련 바이오마커 개발 연구 - 2020.03.01 ~ 2021.02.28
    14. 자가면역관절염 동물 모델에서의 EC-18의 간질성폐질환 발생 억제 효능 평가 및 기전 규명 - 2020.01.01 ~ 2020.12.31
    15. 강직척추염 환자의 척추강직 관련 바이오마커 개발 연구 - 2019.06.01 ~ 2020.02.29
    16. 루푸스신염 환자 소변 단백질 PTM 분석 및 항체를 이용한 루푸스신염 조기진단 키트 개발 - 2019.01.01 ~ 2019.12.31
    17. 강직척추염 환자에서 포도막염 발생 예측 인자 발굴(3) - 2018.11.01 ~ 2019.10.31
    18. TNF억제제를 처방 받은 국내 강직 척추염 환자의 치료패턴, 치료 만족도 및 생산성 손실에 관한 연구 - 2018.06.04 ~ 2019.08.31
    19. 강직척추염 환자에서 포도막염 발생 예측 인자 발굴(2) - 2017.11.01 ~ 2018.10.31
    20. 염증성 근병증의 병인 규명과 생물학적 표지자 개발을 위한 코호트 구축 - 2017.10.19 ~ 2027.07.30
    21. 소변 단백질을 이용한 루푸스 신염 진단 및 활성도 평가 키트 개발 - 2017.01.01 ~ 2017.12.31
    22. 강직척추염 환자에서 포도막염 발생 예측 인자 발굴(1) - 2016.11.01 ~ 2017.10.31
    23. PPM1A를 이용한 강직성척추염 발병기전 연구 및 치료 표적 후보물질 가능성 평가(3) - 2016.05.01 ~ 2017.04.30
    24. 강직성척추염 관련 포도막염 진단 및 예측 바이오마커 개발 - 2016.01.01 ~ 2016.06.30
    25. 강직성척추염 관련 포도막염 진단 및 예측 바이오마커 개발 - 2015.07.01 ~ 2015.12.31
    26. PPM1A를 이용한 강직성척추염 발병기전 연구 및 치료 표적 후보물질 가능성 평가(2) - 2015.05.01 ~ 2016.04.30
    27. 인터루킨-32을 이용한 강직성 척추염 환자의 이상 골 형성 기전 규명 - 2015.01.01 ~ 2015.12.31
    28. PPM1A를 이용한 강직성척추염 발병기전 연구 및 치료 표적 후보물질 가능성 평가(1) - 2014.11.01 ~ 2015.04.30
    29. 강직성 척추염에서 세포 내 PPM1A 발현과 항 PPM1A 항체의 역할 규명(2) - 2014.06.01 ~ 2015.05.31
    30. 인터루킨-32을 이용한 강직성 척추염 환자의 이상 골 형성 기전 규명 - 2014.01.01 ~ 2014.12.31
    31. 류마티스 관절염 환자에서 Etanercept 및 Infliximab 혈중 농도 측정법 검증 - 2013.06.07 ~ 2014.06.17
    32. 강직성 척추염에서 세포 내 PPM1A 발현과 항 PPM1A 항체의 역할 규명 - 2013.06.01 ~ 2014.05.31
    33. IL-32의 골모세포 분화 및 활성화에 미치는 영향에 관한 연구 - 2010.05.01 ~ 2011.04.30

    특허/기술이전실적

    1. 강직성 척추염 환자의 방사선학적 진행 고위험군 선별용 마커 및 이의 용도 - 2023.08.29
    2. 신약 재창출 후보 선정 방법 및 시스템 - 2022.08.30
    3. IGBP1을 포함하는 루프스 신염 진단용 바이오 마커 조성물 - 2018.06.21

    국내외 경력

    Managing editor in the Journal of Rheumatic Diseases (2014.05 ~)

     공지