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1. Tau acetylation at K280 regulates tau phosphorylation [ INTERNATIONAL JOURNAL OF NEUROSCIENCE ] - 2023.12.01
2. Neuronal MHC-I complex is destabilized by amyloid-β and its implications in Alzheimer's disease [ Cell and Bioscience ] - 2023.09.29
3. Monoclonal antibody Y01 prevents tauopathy progression induced by lysine 280-acetylated tau in cell and mouse models [ JOURNAL OF CLINICAL INVESTIGATION ] - 2023.04.17
4. TLQP-21 mediated activation of microglial BV2 cells promotes clearance of extracellular fibril amyloid-beta [ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ] - 2020.04.09
5. V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function [ NEUROBIOLOGY OF DISEASE ] - 2019.09.01
6. Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease [ MOLECULAR AND CELLULAR NEUROSCIENCE ] - 2019.03.01
7. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects [ MOLECULAR PSYCHIATRY ] - 2017.11.01
8. Sorting nexin-4 regulates β-amyloid production by modulating β-site-activating cleavage enzyme-1 [ Alzheimers Research & Therapy ] - 2017.01.21
9. Alzheimer's disease genes and autophagy. [ BRAIN RESEARCH ] - 2016.10.15
10. c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration. [ BMB Reports ] - 2016.07.01
11. Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease [ AGING CELL ] - 2015.10.01
12. α-secretase cleaved APP accumulates in cholinergic dystrophic neurites in normal, aged hippocampus [ NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY ] - 2013.12.01
13. CA-074Me, a cathepsin B inhibitor, decreases APP accumulation and protects primary rat cortical neurons treated with okadaic acid [ NEUROSCIENCE LETTERS ] - 2013.07.05
14. Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures [ NEUROBIOLOGY OF DISEASE ] - 2012.04.02
15. zVLL-CHO at low concentrations acts as a calpain inhibitor to protect neurons against okadaic acid-induced neurodegeneration [ NEUROSCIENCE LETTERS ] - 2012.02.10
16. Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells [ NEUROBIOLOGY OF DISEASE ] - 2010.11.15
17. ACTIVATION OF EUKARYOTIC INITIATION FACTOR-2 alpha-KINASES IN OKADAIC ACID-TREATED NEURONS [ NEUROSCIENCE ] - 2010.09.15
18. Maintained activity of glycogen synthase kinase-3 beta despite of its phosphorylation at serine-9 in okadaic acid-induced neurodegenerative model [ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ] - 2010.04.30
19. Coxsackievirus B4 uses autophagy for replication after calpain activation in rat primary neurons [ JOURNAL OF VIROLOGY ] - 2008.12.02
20. Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease [ JOURNAL OF NEUROSCIENCE RESEARCH ] - 2008.11.01
21. Dynein cleavage and microtubule accumulation in okadaic acid-treated neurons [ NEUROSCIENCE LETTERS ] - 2008.06.01
22. Reduction of mint1, mint2 and APP overexpression in okadaic acid-treated neurons [ NEUROREPORT ] - 2007.12.03
23. Methotrexate, a folate antagonist, decreases PP2A methylation and increases tau phosphorylation and APP accumulation in primary neuron cultures: Implications for Alzheimer's disease [ BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ] - 2007.11.16
24. Calpain activation in okadaic acid induced neurodegeneration [ NEUROREPORT ] - 2006.05.15
25. BACE inhibitor reduces APP--C-terminal fragment accumulation in axonal swellings of okadaic acid-induced neurodegeneration [ NEUROBIOLOGY OF DISEASE ] - 2006.05.01
26. Okadaic acid induces JNK activation, Bim overexpression and mitochondrial dysfunction in cultured rat cortical neurons [ NEUROSCIENCE LETTERS ] - 2006.02.22
27. Increases in TH immunoreactivity, neuromelanin and degeneration in the substantia nigra of middle aged mice. [ NEUROSCIENCE LETTERS ] - 2005.12.22
28. Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures [ CELL MOTILITY AND THE CYTOSKELETON ] - 2005.04.01
29. Inactivation of GSK-3b in okadaic acid-induced neurodegeneration: relevance to Alzheimer’s Disease [ NEUROREPORT ] - 2005.02.28
30. Roles of stem cell factor and c-kit receptor in the development of cerebella GABAergic neurons [ 대한해부학회지 ] - 2004.10.01
31. Construction of a Vector Generating both siRNA and a Fluorescent Reporter: a siRNA Study in Cultured Neurons [ MOLECULES AND CELLS ] - 2004.03.01
32. Concomitant distribution shift of glial GABA transporter and S100 calcium-binding proteins in the rat retina after kainate-induced excitotoxic injury [ NEUROSCIENCE LETTERS ] - 2003.12.15
33. Characteristics of Apoptotic Cell Death Induced by Coxsackievirus B in Permissive Vero Cells [ INTERVIROLOGY ] - 2003.08.30
34. Coxsackievirus B3 Induces Apoptosis in the Early Phase of Murine Myocarditis:A Comparative Analysis of Cardiovirulent and Noncardiovirulent Strains [ INTERVIROLOGY ] - 2003.07.01
35. Differential regulation of mrtallothinein-1,2,and 3 mRNA expression in the rat brain following kainic acid treatment [ NEUROREPORT ] - 2003.04.15
36. Upregulation of catecholamine enzymes by nitric oxide [ JOURNAL OF NEUROSCIENCE RESEARCH ] - 2003.04.01
37. Upregulation of c-kit receptor and stem cell factor in cerebellar inhibitory synapses in response to kainic acid [ JOURNAL OF NEUROSCIENCE RESEARCH ] - 2003.03.01
38. Effect of the abdominal midline incision on the survival of the transverse rectus abdominis musculocutaneous flap in Rat Model [ ANNALS OF PLASTIC SURGERY ] - 2003.03.01

1. 신규 치매모델 평가 및 병인기전 규명 - 2020.01.01 ~ 2020.12.31
2. 알츠하이머 병의 초기 병리기전 규명과 응용모델 개발 - 2019.03.01 ~ 2020.02.29
3. 신규 치매모델 평가 및 병인기전 규명 - 2019.01.01 ~ 2019.12.31
4. 지각학습유도를 통한 만성 통증에 대한 신치료법 개발 - 2018.04.01 ~ 2019.02.28
5. 알츠하이머 병의 초기 병리기전 규명과 응용모델 개발 - 2018.03.01 ~ 2019.02.28
6. 알츠하이머 병의 초기 병리기전 규명과 응용모델 개발 - 2017.03.01 ~ 2018.02.28
7. 세포와 동물모델에서 타우의 병리학적 조절(3) - 2017.03.01 ~ 2018.02.28
8. 세포기능장애 연구센터(4) - 2016.09.01 ~ 2017.08.31
9. 세포와 동물모델에서 타우의 병리학적 조절(2) - 2016.03.01 ~ 2017.02.28
10. 세포기능장애 연구센터(3) - 2015.09.01 ~ 2016.08.31
11. 세포와 동물모델에서 타우의 병리학적 조절(1) - 2015.03.01 ~ 2016.02.29
12. 세포기능장애 연구센터(2) - 2014.09.01 ~ 2015.08.31
13. 치매 진단 키트 개발 - 2014.07.21 ~ 2014.10.20
14. 세포기능장애 연구센터(1) - 2013.09.01 ~ 2014.08.31
15. 알츠하이머병의 병인에 관여하는 세포기능장애 기전연구(3) - 2012.09.01 ~ 2013.08.31
16. 알츠하이머병의 병인에 관여하는 세포기능장애 기전연구[2] - 2011.09.01 ~ 2012.08.31
17. 알츠하이머병의 병인에 관여하는 세포기능장애 기전연구 - 2010.09.01 ~ 2011.08.31
18. 알츠하이머병과 당뇨병의 병인기전연구와 세포보호제 개발연구 - 2009.09.01 ~ 2010.08.31
19. 세포모델을 이용한 알쯔하이머병 병인기전연구와 GSK-3B를 타겟으로한 치료제 개발 연구 (2) - 2009.04.01 ~ 2010.03.31
20. 알츠하이머병과 당뇨병의 병인기전연구와 세포보호제 개발연구 - 2008.09.01 ~ 2009.08.31
21. 세포모델을 이용한 알쯔하이머병 병인기전연구와 GSK-3β를 타켓으로 한 치료제 개발 연구 - 2008.05.01 ~ 2009.03.31
22. 알쯔하이머병의 병인기전에서 치료를 위한 표적 발굴(4) - 2007.04.01 ~ 2008.03.31
23. 알쯔하이머병의 병인기전에서 치료를 위한 표적 발굴[3] - 2006.04.01 ~ 2007.03.31
24. 알쯔하이머병의 병인기전: 진단과 치료를 위한 표적 발굴 - 2005.05.01 ~ 2006.03.31
25. 알쯔하이머 병의 병인기전: 진단과 치료를 위한 표적발굴 - 2004.05.01 ~ 2005.04.30
26. Coxakievirus B3와 변이체의 neurotropism 과 신경세포의 사멸기전에 대한 연구(2) - 2004.05.01 ~ 2005.04.30
27. Coxakievirus B3와 변이체의 neurotropism 과 신경세포의 사멸기전에 대한 연구(1) - 2003.07.01 ~ 2004.04.30
28. 알쯔하이머병의 in vitro 연구모델 개발 : Okadaic acid로 유도한 신경퇴행모델에서 신경세포사멸의 기전 연구(3) - 2003.05.01 ~ 2004.04.30
29. 알쯔하이머병의 in vitro 연구모델 개발 : Okadaic acid로 유도한 신경퇴행모델에서 신경세포사멸의 기전 연구(2) - 2002.05.01 ~ 2003.04.30
30. 알쯔하이머병의 in vitro 연구 모델개발 : okadaic acid로 유도한 신경퇴행모델에서 신경세포사멸의 기전연구(1)-국립보건원세부 - 2001.06.01 ~ 2002.04.30

1. 알츠하이머 질환에서 ＧＳＫ－３β 억제제 스크리닝을 위한오카다익산 유도성 신경세포 퇴행모델 - 2011.12.07
2. 웹데브 기반의 그룹 작업공간 지원을 위한 클라이언트 - 2006.08.11

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